annotated library set of 13,000 bioactive compounds Search Results


annotated library set of 13,000 bioactive compounds  (AstraZeneca ltd)
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AstraZeneca ltd annotated library set of 13,000 bioactive compounds
High-throughput screening performance of <t>bioactive</t> compounds in hiPSC-Hep. ( A ) Integrated spot signal (ISS) vs. valid cell count in 2D scatter plot for hiPSC-Hep seeded at 24K (green, Z’ = 0.38), 30K (pink, Z’ = 0.57) and 36K (blue, Z’ = 0.62) per well cell densities. Average of TG/FA treated wells (green squares) and average of BSA-treated cells (blue dots) per screening plate for ( B ) ISS relative values of BODIPY 493/503 fluorescence imaged in the green channel and ( C ) valid cell count relative to values of Hoechst 33342 fluorescence detected in the blue channel. Each data point represents the mean relative ISS from six fields per well and the average of 16 wells per plate. ( D ) Determined Z’ scores (dark green line) and robust Z’ scores (RZ’ light green line) calculation for ISS values in TG/FA vs. BSA treated controls per assay plate.
Annotated Library Set Of 13,000 Bioactive Compounds, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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annotated library set of 13,000 bioactive compounds - by Bioz Stars, 2026-10
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High-throughput screening performance of bioactive compounds in hiPSC-Hep. ( A ) Integrated spot signal (ISS) vs. valid cell count in 2D scatter plot for hiPSC-Hep seeded at 24K (green, Z’ = 0.38), 30K (pink, Z’ = 0.57) and 36K (blue, Z’ = 0.62) per well cell densities. Average of TG/FA treated wells (green squares) and average of BSA-treated cells (blue dots) per screening plate for ( B ) ISS relative values of BODIPY 493/503 fluorescence imaged in the green channel and ( C ) valid cell count relative to values of Hoechst 33342 fluorescence detected in the blue channel. Each data point represents the mean relative ISS from six fields per well and the average of 16 wells per plate. ( D ) Determined Z’ scores (dark green line) and robust Z’ scores (RZ’ light green line) calculation for ISS values in TG/FA vs. BSA treated controls per assay plate.

Journal: International Journal of Molecular Sciences

Article Title: Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation

doi: 10.3390/ijms21249557

Figure Lengend Snippet: High-throughput screening performance of bioactive compounds in hiPSC-Hep. ( A ) Integrated spot signal (ISS) vs. valid cell count in 2D scatter plot for hiPSC-Hep seeded at 24K (green, Z’ = 0.38), 30K (pink, Z’ = 0.57) and 36K (blue, Z’ = 0.62) per well cell densities. Average of TG/FA treated wells (green squares) and average of BSA-treated cells (blue dots) per screening plate for ( B ) ISS relative values of BODIPY 493/503 fluorescence imaged in the green channel and ( C ) valid cell count relative to values of Hoechst 33342 fluorescence detected in the blue channel. Each data point represents the mean relative ISS from six fields per well and the average of 16 wells per plate. ( D ) Determined Z’ scores (dark green line) and robust Z’ scores (RZ’ light green line) calculation for ISS values in TG/FA vs. BSA treated controls per assay plate.

Article Snippet: We collaborated with AstraZeneca Open Innovation Group and obtained a copy of their annotated library set of 13,000 bioactive compounds.

Techniques: High Throughput Screening Assay, Cell Counting, Fluorescence